department of chemistry and biochemistry
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Eamonn F. Healy


Professor of Chemistry
Office: JBWN 215
SEU Box: 805   e-mail : healy@stedwards.edu

Phone: (512) 448-8467

Education

  • University College Cork, Ireland,    1976-1980                   B.S.   Chemistry.

  • University of Texas at Austin,         1980-1984                   Ph.D. Chemistry.

Research Interests

The general focus of our research involves the use of molecular modeling to design structure-activity probes for the purpose of elucidating enzymatic activity. Recent targets have included HIV-1 integrase, the c-Kit and src-abl proteins associated with tumor development and certain leukemias, and the metalloproteinases associated with the shedding of chemokine CXCL16. We have also developed in silico characterizations of the mechanism of action of the Mtb alpha-crystallin protein, and models for the heat shock response of Escherichia coli and for the observed suppression of spinocerebellar ataxia by human alphaB-crystallin. A more detailed description of this research can be be viewed at the link shown to the right.

Teaching Interests

A full listing of my courses, with syllabi and class materials, can be viewed at the link shown to the right.

Recent Publications

Eamonn F. Healy, Carley Little† and Peter J. King “A model for small heat shock protein inhibition of polyglutamine aggregation”, Cell Biochem. Biophys. doi: 10.1007/s12013-013-9795-1 .

Eamonn F. Healy “Michael J. S. Dewar: A Model Iconoclast” In Pioneers of Quantum Chemistry, E. Thomas Strom, Angela K. Wilson , Eds. , ACS Symposium Series, Vol. 1122; American Chemical Society: Washington, DC, 2013 pp 139–153. doi: 10.1021/bk-2013-1122.ch005 .

Eamonn F. Healy,  "A model for heterooligomer formation in the heat shock response of E. coli.", Biochem. Biophys. Res. Commun., 2012, 420, 639-643.doi: 10.1016/j.bbrc.2012.03.054.

Eamonn F. Healy, and Peter J. King "A Mechanism of Action for Small Heat Shock Proteins" , Biochem. Biophys. Res. Commun., 2012, 417, 268–273. doi:10.1016/j.bbrc.2011.11.098.

E.F. Healy, “Heisenberg's Chemical Legacy: Resonance and the Chemical Bond”, Foundations of Chemistry, 2011, 13, 39-49;doi: 10.1007/s10698-011-9104-2 .

E.F. Healy, “The effect of desolvation on nucleophilic halogenase activity”, Computational and Theoretical Chemistry, 2011, 964, 91-93; doi: 10.1016/j.comptc.2010.12.003.

Eamonn F. Healy, Pablo Romano†, Moises Mejia† and Gunnar Lindfors III†, Acetylenic Inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity  J. Mol. Graph. Model.,2010, 29,  436-442; doi:10.1016/j.jmgm.2010.08.006.

Eamonn F. Healy, Samuel Manzer, Jeffrey Gorman, Alicia Jones† and Nicholas Cristea† "A dramatic heavy atom effect in the quenching of dichlorosubstituted lucigenin fluorescence", Chem. Phys. Lett., 2010, 485 , 258-261; doi:10.1016/j.cplett.2009.12.049.
 
E.F. Healy “In Defense of a Heuristic Interpretation of Quantum Mechanics”, J. Chem. Educ., 2010, 87 , 559-563; doi: 10.1021/ed8001545.

Eamonn F. Healy , Skylar Johnson† , Charles Hauser, and Peter King “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.”  FEBS Lett.  2009, 583, 2899-2906; doi:10.1016/j.febslet.2009.07.051.

Eamonn F. Healy, Jonathan Sanders†, Peter J. King and W. Edward Robinson, Jr “A Docking Study of L-Chicoric Acid with HIV-1 Integrase” J Mol. Graph. Model. 2009, 27 , 14; doi:10.1016/j.jmgm.2008.09.011.


            † student author

All Publications


Recent Professional Presentations

 Paper COMP 193 “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl ”,Eamonn F Healy, presented at the 244th  National Meeting of the American Chemical Society in Philadelpha, Fall 2012.

 Paper CHED 360 “Acetylenic inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity”, Pablo G Romano *, Moises Mejia* , Eamonn F Healy, presented at the 243rd  National Meeting of the American Chemical Society in San Diego, Spring 2012.

Paper CHED 206 “Resveratrol effects on PGHS-1 using molecular modeling: Applications in biochemistry”, Brenna Sura*, Eamonn F Healy, presented at the 243rd  National Meeting of the American Chemical Society in San Diego, Spring 2012.

 “A role for Heat Shock Proteins in the formation of the tuberculous granuloma”, Eamonn F. Healy, 2011 Lucian Symposium, Global Health and Infectious Disease: Tuberculosis, October 2011.

"This House Fears the rise of Artificial Intelligence," Eamonn F. Healy, University Philosophical Society in Trinity College Dublin (debate) December 2011.

"The Role of Desolvation in Ligand Binding and Protein Aggregation," Eamonn F. Healy , Departments of Biochemistry and Immunology , Trinity College, Dublin, Ireland , December 2011.

Presenters are underlined; undergraduate student authors are noted by asterisks.

 

 

 

 

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RESEARCH


CLASSES

 

LUCIAN SYMPOSIUM 2010

 

LUCIAN SYMPOSIUM 2011

 

LUCIAN SYMPOSIUM 2012

 

LUCIAN SYMPOSIUM 2013