Professor of Chemistry
Office: JBWN 215
SEU Box: 805 e-mail : healy@stedwards.edu
Phone: (512) 448-8467
Education
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University College Cork, Ireland, 1976-1980 B.S. Chemistry.
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University of Texas at Austin, 1980-1984 Ph.D. Chemistry.
Research Interests
Our research focuses on the design of structure-activity probes to elucidate enzymatic activity. The interdisciplinary approach includes molecular modeling for the simulation of inhibitor binding , overexpression of the target proteins and in vitro assays of enzymatic activity and inhibition. Our targets include HIV-1 integrase, the c-Kit and src-abl proteins , and the metalloproteinases associated with CXCL16 shedding. A more detailed description of this research can be be viewed at the link shown to the right.
Teaching Interests
A full listing of my courses, with syllabi and class materials, can be viewed at the link shown to the right.
Recent Publications
Eamonn F. Healy “Michael J. S. Dewar: A Model Iconoclast” In Pioneers of Quantum Chemistry, E. Thomas Strom, Angela K. Wilson , Eds. , ACS Symposium Series, Vol. 1122; American Chemical Society: Washington, DC, 2013 pp 139–153. doi: 10.1021/bk-2013-1122.ch005 .
Eamonn F. Healy, "A model for heterooligomer formation in the heat shock response of E. coli.", Biochem. Biophys. Res. Commun., 2012, 420, 639-643.doi: 10.1016/j.bbrc.2012.03.054.
Eamonn F. Healy, and Peter J. King "A Mechanism of Action for Small Heat Shock Proteins" , Biochem. Biophys. Res. Commun., 2012, 417, 268–273. doi:10.1016/j.bbrc.2011.11.098.
E.F. Healy, “Heisenberg's Chemical Legacy: Resonance and the Chemical Bond”, Foundations of Chemistry, 2011, 13, 39-49;doi: 10.1007/s10698-011-9104-2 .
E.F. Healy, “The effect of desolvation on nucleophilic halogenase activity”, Computational and Theoretical Chemistry, 2011, 964, 91-93; doi: 10.1016/j.comptc.2010.12.003.
Eamonn F. Healy, Pablo Romano†, Moises Mejia† and Gunnar Lindfors III†, Acetylenic Inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity J. Mol. Graph. Model.,2010, 29, 436-442; doi:10.1016/j.jmgm.2010.08.006.
Eamonn F. Healy, Samuel Manzer, Jeffrey Gorman, Alicia Jones† and Nicholas Cristea† "A dramatic heavy atom effect in the quenching of dichlorosubstituted lucigenin fluorescence", Chem. Phys. Lett., 2010, 485 , 258-261; doi:10.1016/j.cplett.2009.12.049.
E.F. Healy “In Defense of a Heuristic Interpretation of Quantum Mechanics”, J. Chem. Educ., 2010, 87 , 559-563; doi: 10.1021/ed8001545.
Eamonn F. Healy , Skylar Johnson† , Charles Hauser, and Peter King “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.” FEBS Lett. 2009, 583, 2899-2906; doi:10.1016/j.febslet.2009.07.051.
Eamonn F. Healy, Jonathan Sanders†, Peter J. King and W. Edward Robinson, Jr “A Docking Study of L-Chicoric Acid with HIV-1 Integrase” J Mol. Graph. Model. 2009, 27 , 14; doi:10.1016/j.jmgm.2008.09.011.
† student author
All Publications
Recent Professional Presentations
Paper COMP 193 “Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl ”,Eamonn F Healy, presented at the 244th National Meeting of the American Chemical Society in Philadelpha, Fall 2012.
Paper CHED 360 “Acetylenic inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity”, Pablo G Romano *, Moises Mejia* , Eamonn F Healy, presented at the 243rd National Meeting of the American Chemical Society in San Diego, Spring 2012.
Paper CHED 206 “Resveratrol effects on PGHS-1 using molecular modeling: Applications in biochemistry”, Brenna Sura*, Eamonn F Healy, presented at the 243rd National Meeting of the American Chemical Society in San Diego, Spring 2012.
“A role for Heat Shock Proteins in the formation of the tuberculous granuloma”, Eamonn F. Healy, 2011 Lucian Symposium, Global Health and Infectious Disease: Tuberculosis, October 2011.
"This House Fears the rise of Artificial Intelligence," Eamonn F. Healy, University Philosophical Society in Trinity College Dublin (debate) December 2011.
"The Role of Desolvation in Ligand Binding and Protein Aggregation," Eamonn F. Healy , Departments of Biochemistry and Immunology , Trinity College, Dublin, Ireland , December 2011.
Presenters are underlined; undergraduate student authors are noted by asterisks.
