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TOPIC: Organic, Inorganic and Biochemical
analysis
CASE STUDY I : "False
Cyanide Detection", Anal. Chem., March 1, 2002 /
volume 74, issue 5 /pp 134 A-141 A ;
"Assessing
Exposure of Marine Biota and Habitats to Petroleum Compounds",
Anal. Chem., March 1, 1998; pp. 186 A-192 A..
LINKS:
Neutron
Activation Analysis
JFK
Assassination Video
JFK Assassination
Files
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TOPIC: Drug Analysis
- Outline the legal classification of drugs of abuse within
the US system, including examples.
- Discuss the main types of commonly abused drugs, with
particular reference to their chemical nature, physical
forms and effects.
- Explain the different factors that influence the toxicity
of a substance.
- Appreciate the different routes of uptake of toxic compounds
into the human body and the means by which they are subsequently
eliminated.
- Review the information sought during the analysis of samples
for drugs and recognise the means by which such analyses
may be carried out.
Outline:
- Organic Structure
- Physical, Chemical and Spectroscopic properties
- Biochemical function and metabolism
- Pharmacological action
- Natural origin and Classification
- Synthesis and manufacture
- Detection : physical, chemical and instrumental
CASE STUDY I : "Drugs
on Money", Anal. Chem., June 1, 2000; pp. 397 A-403
A
LINKS:Drugs
Forensic Toxicology
Lycaeum
TextI
DrugDatabsae
Animated
GC Movie
HPLC
Electrophoresis
MS
for the Novice
GC/MS
For Chromatographers
Animated
GC/MS Movie
Mass
Spec Tutorial
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TOPIC: Forensic Toxicology
- Describe the main groups of poisons.
- Discuss the main types ofpoisons with particular reference
to their chemical nature, physical forms and effects.
- Explain the different factors that influence the toxicity
of a substance.
- Appreciate the different routes of uptake of toxic compounds
into the human body and the means by which they are subsequently
eliminated.
- Review the information sought during the analysis of poisons
and recognise the means by which such analyses may be carried
out.
OUTLINE:
- Chemical Structure
- Physical, Chemical and Spectroscopic properties
- Biochemical function and metabolism
- Physiological action
- Natural origin and method of delivery
- Tolerance and cross tolerance
- Detection : physical, chemical and instrumental
CASE STUDY I : "Toxicants
in the Environment:Are we being exposed?", Anal.
Chem., December 1, 1998; pp. 797 A-799 A ; "Arsenic
Speciation", Anal. Chem., Volume 76, Issue 1
pp 1 A–40 A.
LINKS:
Forensic Toxicology
Lycaeum
TextI
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TOPIC: Combustion and Explosion
- Understand what is meant by the term fire and the conditions
that are required for fire to occur.
- Distinguish between the natures of smouldering combustion
and flaming combustion and why one of these may become the
other.
- Describe how fire behaves in rooms and similar compartments,
and outdoors.
- Appreciate why fires are investigated.
- Explain why it is wise to approach a fire scene as if
it were a crime scene until and unless it is known not to
be.
- Understand the principles that allow fire scene investigations
to establish the seat and cause of a fire and whether or
not it was intentionally started.
- Recognise the role of laboratory chemical analysis in
the investigation of suspicious fires.
- Define what is meant by the terms explosion and explosive.
- Describe how explosions and explosives may be classified.
- Understand the basic principles of explosion scene investigation.
- List the means by which samples may be analysed for the
presence of explosives.
- Recognise the forensic value of the detection and/or identification
of explosives, whether by chemical analysis or other means,
and the steps that need to be taken to ensure that the interpretation
of such information is valid.
OUTLINE:
- Nature of combustion, flammability and ignition
- Properties of boiling point, flash point and heat output
- Properties of ignition temperature, vapor pressure and
vapor
- content
- Convection, conduction and radiation of heat
- Physical and chemical properties of accelerants
- Instrumental methods of accelerant detection
- Chemical process of explosion
- Nature and classification of explosives
- Volume, work and velocity of explosion products
- Instrumental methods of explosive detection
CASE STUDY I : "A
Detection of Explosives by Electronic Noses.", Anal.
Chem., Volume 75, Issue 5
pp 81 A–128 A ; "Chemical Analysis of Arson Debris",
Anal. Chem., Volume 68 (1996),
pp 541A
LINKS:
Arson
Explosives
Federal
Explosives Law
TextI
TextII
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TOPIC: DNA : Profiling and Fingerprinting
- Understand the nature of DNA and its relationship to genes.
- Appreciate that genetic differences between individuals
can be revealed by examining their DNA.
- Comprehend the technology of DNA analysis.
- Understand the application of the technology to produce
DNA profiles.
- Conduct a basic analysis and interpretation of a DNA profile.
- Appreciate the impact of DNA profiling on forensic investigations.
OUTLINE:
- Restriction Fragment Length Polymorphism analysis
- Variable Number Tandem Repeat analysis
- Short Tandem Repeat analysis
- Mitochondrial DNA analysis
- Population genetics and Hardy-Weinberg equilibrium
- Allele frequency and the CODIS database
- Power of Discrimination & Power of Exclusion
CASE STUDY I : "The
Forensic Community’s Response to September 11",
Anal. Chem., April 1, 2002 / volume 74, issue 7 /
pp 190 A-195 A
LINKS:
DNA
From the Beginning
PCR
Graphic
RFLP
Analysis
Forensic
DNA
TextI
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